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Five innovative biomedical engineering

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Five innovative developments in biomedical engineering are described in the study.

The IEEE Engineering in Medicine and Biology Society (IEEE EMBS) and IEEE, the largest technical professional organization in the world committed to advancing technology for humanity, released a comprehensive position Grand Challenges at the Interface of Engineering and Medicine is a study that addresses biomedical engineering today.

A group of 50 researchers from 34 different institutions worldwide collaborated to write the study, which was published in the IEEE Open Journal of Engineering in Medicine and Biology (IEEE OJEMB). This work set the stage for a coordinated global endeavor to develop new technologies and medical treatments.

Said Dr. Michael Miller, senior author of the publication and director of the Department of Biomedical Engineering at Johns Hopkins University, What we’ve done here will serve as a roadmap for innovative studies that will change the medical field in the next ten years. The task force’s recommendations, which include substantial chances for training and research, are expected to have a long-term impact on engineering and medical.

The Department of Biomedical Engineering at Johns Hopkins University and the Department of Bioengineering at the University of California San Diego collaborated with IEEE EMBS to conduct a two-day workshop that produced the position paper. The researchers discovered throughout the workshop five main medical issues that still need to be resolved but that, when done so using cutting-edge biomedical engineering techniques, might significantly enhance human health.

Paolo Bonato, Ph.D., an associate professor of physical medicine and rehabilitation at Harvard Medical School, member of Mass General Brigham, and head of the Motion Analysis Laboratory at Spaulding Rehabilitation, was among the attendees of the workshop.

According to Bonato, this book represents a singular contribution from fifty prominent figures in the field of biomedical engineering, outlining areas of upcoming technological advancements that are anticipated to enable sophisticated precision medicine treatments.

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Biology and technology advancements will play a major role in medicine in the future. To this end, we can gather an unparalleled quantity of high-quality data that will power digital twin models and help create personalized treatment regimens for patients, as well as anticipate and stop the onset of diseases.

The consortium member Dr. Metin Akay, founding chair of the Biomedical Engineering Department at the University of Houston and Ambassador of IEEE EMBS, noted that this paper represents a significant milestone in the advancement of biomedical engineering, which could only have been accomplished through close collaboration rather than the work of many siloed individuals.

Our common goals are to advance patient-centered technology, increase health care accessibility and efficacy outside of academic institutions, and improve health care quality, lower costs, and enhance lives all across the world.

The group has outlined a research and finance strategy for biomedical engineering by concentrating on these five medical challenges:

Linking precision medicine and precision engineering to create customized physiology avatars

Our increasingly digital age has given us access to technology that collect vast volumes of patient data, which physicians may use or supplement. By using this data to create precise physiology models, or “avatars,” that account for concomitant medications, multimodal measurements and comorbidities, potential risks, and costs, hyper-personalized care, diagnosis, and treatment can be made possible for individual patient data.

Cutting-edge technology like digital twins and wearable sensors can serve as the cornerstone of a solution to this problem.

The quest for human health via on-demand tissue and organ engineering

The field of tissue engineering is about to hit a turning point when it will be possible to create tissues and organs on demand as either temporary or permanent implants.

Important developments in stem cell manufacture and engineering, as well as auxiliary technologies like gene editing, are needed to guide the expansion of this modality. Soon, it will be possible to create further stem cell tools, like organ-on-a-chip technology, with a patient’s own cells. These tools will be able to function as “avatars” and make customized predictions.

advancing neuroscience by developing cutting-edge brain-interface technologies with artificial intelligence (AI)

AI gives us the chance to noninvasively identify abnormal brain function by analyzing the many states of the brain in everyday life and functioning. Although developing technology that can accomplish this is a huge challenge, it is becoming more and more feasible. Brain prostheses can lessen the burden of sickness brought on by neurological disorders by augmenting, replacing, or supplementing functions.

Furthermore, the synthesis of neural organoids and AI modeling of brain physiology, morphology, and behavior might help us better understand and cure these disorders by revealing the intricacies of the brain.

Immune system engineering for wellbeing and health

Having gained a deeper comprehension of the basic science behind the immune system, we can now strategically leverage the immune system to reimagine human cells as vital therapeutic and medical solutions.

The use of immunotherapy to treat cancer offers proof of the integration of engineering principles with advances in protein engineering, functional genomics, nanomedicine technology, and vaccines as well as genome, epigenome, and vaccine innovations.

constructing and designing genomes for genomic disruptions and organism repurposing

Even with the recent decades’ fast progress in genomics, challenges still stand in the way of our capacity to create genomic DNA. When it comes to developing new cell-based therapies, efficiently using the transcriptome and epigenome, and engineering new functionality into human cells, our understanding of the design principles of the human genome and its activity can help us find answers to a wide range of disorders.

Beyond that, there are still significant obstacles to overcome in the area of gene delivery techniques for in vivo gene engineering, an issue for which biomedical engineering is part of the solution.

According to Lead task force author Dr. Shankar Subramaniam is a distinguished professor at the University of California San Diego’s Shu Chien-Gene Lay Department of Bioengineering and a former president of IEEE EMBS, these grand challenges present exceptional opportunities that can revolutionize the practice of engineering and medicine.

The emergence of humanoid avatars, multi-scale sensors and gadgets, and AI-powered, remarkably realistic prediction models have the potential to fundamentally alter our way of life and how we react to diseases. Institutions have the power to transform biomedical and engineering education, preparing the brightest minds to tackle the biggest challenge of our time: human health.

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